The Knee
Volume 17, Issue 2 , Pages 157-160 , March 2010

Association of the calcitonin gene (CA) polymorphism with osteoarthritis of the knee in a Mexican mestizo population

  • J.J. Magaña

      Affiliations

    • Department of Genetics, National Rehabilitation Institute, Mexico City, Mexico
    • ,
  • A. Gálvez-Rosas

      Affiliations

    • Department of Genetics, National Rehabilitation Institute, Mexico City, Mexico
    • Escuela Nacional de Ciencias Biológicas-Instituto Politécnico Nacional (ENCB-IPN), Mexico City, Mexico
    • ,
  • C. González-Huerta

      Affiliations

    • Department of Genetics, National Rehabilitation Institute, Mexico City, Mexico
    • ,
  • C. Duarte-Salazár

      Affiliations

    • Department of Rheumatology Service, National Rehabilitation Institute, Mexico City, Mexico
    • ,
  • L. Lara-Alvarado

      Affiliations

    • Department of Articular Rehabilitation Service, National Rehabilitation Institute, Mexico City, Mexico
    • ,
  • M.A. Soria-Bastida

      Affiliations

    • Department of Articular Rehabilitation Service, National Rehabilitation Institute, Mexico City, Mexico
    • ,
  • S. Cortés-González

      Affiliations

    • Department of Magnetic Resonance, National Rehabilitation Institute, Mexico City, Mexico
    • ,
  • A. Miranda-Duarte

      Affiliations

    • Department of Genetics, National Rehabilitation Institute, Mexico City, Mexico
    • Corresponding Author InformationCorresponding author. Calzada México-Xochimilco No. 289, Col. Arenal Guadalupe, 14389 México, D.F., Mexico. Tel.: +52 55 5999 1000x19406; fax: +52 55 5603 9127.

Received 31 March 2009 ,Revised 11 August 2009 ,Accepted 13 August 2009.

References 

  1. Dieppe PA, Lohmander LS. Pathogenesis and management of pain in osteoarthritis. Lancet. 2005;365:965–973
  2. Peach CA, Carr AJ, Loughlin J. Recent advances in the genetic investigation of osteoarthritis. Trends Mol Med. 2005;11:186–191
  3. Zhang W, Doherty M. How important are genetic factors in osteoarthritis? Contributions from family studies. J Rheumatol. 2005;32:1139–1142
  4. Aigner T, Dudhia J. Genomics of osteoarthritis. Curr Opin Rheumatol. 2003;15:634–640
  5. Ikegawa S. New gene associations in osteoarthritis: what do they provide, and where are we going?. Curr Opin Rheumathol. 2007;19:429–434
  6. Manicourt DH, Devogelaer JP, Azria M, Silverman S. Rationale for the potential use of calcitonin in osteoarthritis. J Musculoskelet Neuronal Interact. 2005;5:285–293
  7. Sondergaard BC, Wulf H, Henriksen K, Schaller S, Oestergaard S, Qvist P, et al. Calcitonin directly attenuates collagen type II degradation by inhibition of matrix metalloproteinase expression and activity in articular chondrocytes. Osteoarthr Cartil. 2006;14:759–768
  8. Karsdal MA, Sumer EU, Wulf H, Madsen SH, Christiansen C, Fosang AJ, et al. Induction of increased cAMP levels in articular chondrocytes blocks matrix metalloproteinase-mediated cartilage degradation, but not aggrecanase-mediated cartilage degradation. Arthritis Rheum. 2007;56:1549–1558
  9. Behets C, Williams JM, Chappard D, Devogelaer JP, Manicourt DH. Effects of calcitonin on subchondral trabecular bone changes and on osteoarthritic cartilage lesions after acute anterior cruciate ligament deficiency. J Bone Miner Res. 2004;19:1821–1826
  10. Karsdal MA, Sondergaard BC, Arnold M, Christiansen C. Calcitonin affects both bone and cartilage: a dual action treatment for osteoarthritis?. Ann N Y Acad Sci. 2007;1117:181–195
  11. Karsdal MA, Byrjalsen I, Henriksen K, Riis BJ, Christiansen C. A pharmacokinetic and pharmacodynamic comparison of synthetic and recombinant oral salmon calcitonin. J Clin Pharmacol. 2009;49:229–234
  12. Lin Z, Pavlos NJ, Cake MA, Wood DJ, Xu J, Zheng MH. Evidence that human cartilage and chondrocytes do not express calcitonin receptor. Osteoarthr Cartil. 2008;16:450–457
  13. Magaña JJ, Gómez R, Cisneros B, Casas L, Castorena F, Miranda A, et al. Association of the CT gene (CA) polymorphism with BMD in osteoporotic Mexican women. Clin Genet. 2006;70:402–408
  14. Kellgren JH, Lawrence JS. Radiological assessment of osteo-arthrosis. Ann Rheum Dis. 1957;16:494–502
  15. Coggon D, Reading I, Croft P, McLaren M, Barret D, Cooper C. Knee osteoarthritis and obesity. Int J Obes Relat Metab Disord. 2001;25:622–627
  16. Sambrook J, Fritsch EF, Maniatis T. Molecular cloning; a laboratory manual. New York: Cold Spring Harbor Laboratory Press; 1989;
  17. Tsukamoto K, Watanabe I, Shiba T, Emi M. Isolation and radiation hybrid mapping of a dinucleotide repeat polymorphism at the human calcium-sensing receptor (CASR) locus. J Hum Genet. 1998;43:280–282
  18. Valdes AM, Loughlin J, Timms KM, van Meurs JJ, Southam L, Wilson SG, et al. Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis. Am J Hum Genet. 2008;82:1231–1240
  19. García-García E, De la Llata-Romero M, Kaufer-Horwitz M, Tusié-Luna MT, Calzada-León R, Vázquez-Velázquez V, et al. Obesity and metabolic syndrome as public health problem. A reflection. Arch Cardiol Mex. 2008;78:318–337
  20. Aerssens J, Dequeker J, Peeters J, Breemans S, Boonen S. Lack of association between osteoarthritis of the hip and gene polymorphisms of VDR, COL1A1, and COL2A1 in postmenopausal women. Arthritis Rheum. 1998;42:1946–1950
  21. Meulenbelt I, Bijkerk C, De Wildt , Miedema HS, Breedveld FC, Pols HAP, et al. Haplotype analysis of three polymorphisms of the COL2A1 gene and associations with generalised radiological osteoarthritis. Ann Hum Genet. 1999;63:393–400
  22. Elston RC. Linkage and association. Genet Epidemiol. 1998;15:565–576
  23. Karsdal MA, Henriksen K, Arnold M, Christiansen C. Calcitonin: a drug of the past or for the future? Physiologic inhibition of bone resorption while sustaining osteoclast numbers improves bone quality. BioDrugs. 2008;22:137–144
  24. Fernihough J, Gentry C, Bevan S, Winter J. Regulation of calcitonin gene-related peptide and TRPV1 in a rat model of osteoarthritis. Neurosci Lett. 2005;388:75–80
  25. Sondergaard BC, Oestergaard S, Christiansen C, Tankó LB, Karsdal MA. The effect of oral calcitonin on cartilage turnover and surface erosion in an ovariectomized rat model. Arthritis Rheum. 2007;56:2674–2678

PII: S0968-0160(09)00148-3

doi: 10.1016/j.knee.2009.08.006

The Knee
Volume 17, Issue 2 , Pages 157-160 , March 2010

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