Abstract
Background
This study sought to assess early clinical outcomes for knee osteoarthritis (OA) patients
undergoing bone marrow aspirate concentrate (BMAC) treatment using a novel closed-end,
fenestrated trocar (FT) that does not require centrifugation.
Methods
A prospective cohort of 17 knee OA patients undergoing BMAC treatment with the FT
system from March 2018 to March 2019 was retrospectively evaluated. Approximately
10 mL of BMAC was harvested, no centrifugation was performed, and the BMAC was injected
into the affected knee. Clinical outcomes were assessed at baseline, six weeks, and
12 weeks. This study has no affiliation with/vested-interest in the FT system.
Results
There were significant improvements in nearly all outcomes from baseline to 12 weeks.
Specific improvements included Knee Injury and OA Outcome Score (KOOS) activities-of-daily-living
(61.1 ± 9.2 [mean ± 95% confidence interval] to 89.3 ± 6, p = 0.001), quality-of-life (32.7 ± 9.3 to 66.1 ± 17.9, p = 0.003), sports/recreation (36.9 ± 10.6 to 72.6 ± 26.3, p = 0.006), and pain (53.8 ± 9.3 to 83 ± 10.2, p = 0.001); Lysholm scores (55.5 ± 8.4 to 77.3 ± 10.5, p = 0.009); and visual analog pain scores (5.68 ± 1.14 to 2.07 ± 1.86, p = 0.003). Individually, at least 75% of patients exhibited improvement in all KOOS
categories at six weeks and at least 85% at 12 weeks.
Conclusions
BMAC treatment with an FT system that does not require centrifugation resulted in
significant improvements in early pain and function scores for knee OA. The symptomatic
improvements in this study were similar to or greater than what has been reported
using traditional needles. These data may provide clinicians with comfort in using
an FT system and provide motivation for future randomized-controlled trials comparing
aspiration techniques.
Keywords
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Article info
Publication history
Accepted:
August 23,
2020
Received in revised form:
June 29,
2020
Received:
January 15,
2020
Identification
Copyright
© 2020 Elsevier B.V. All rights reserved.
